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T cell responses to DosR and Rpf proteins in actively and latently infected individuals from Colombia
09 January 2012
Felipe Riaño, Leonar Arroyo, Sara París, Mauricio Rojas, Annemieke H. Friggen, Krista E. van Meijgaarden, Kees L.M.C. Franken, Tom H.M. Ottenhoff, Luis F. García, Luis F. Barrera
Summary: Mycobacteriumtuberculosis DosR regulon-encoded proteins elicit strong immune T-cell responses in individuals with latent tuberculosis (LTBI). Also, resuscitation (Rpf) proteins can induce suc...
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Identification of Rv0535 as methylthioadenosine phosphorylase from Mycobacterium tuberculosis
06 January 2012
Kajal Buckoreelall, Yanjie Sun, Judith V. Hobrath, Landon Wilson, William B. Parker
Summary: 5′-methylthioadenosine (MTA) is a natural purine that is metabolized by methylthioadenosine phosphorylase (MTAP, E.C 2.4.2.28) in Eukarya and Archaea but generally not in bacteria. In this wo...
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Mycobacterium tuberculosis – Heterogeneity revealed through whole genome sequencing
05 January 2012
Chris Ford, Karina Yusim, Tom Ioerger, Shihai Feng, Michael Chase, Mary Greene, Bette Korber, Sarah Fortune
Summary: The emergence of whole genome sequencing (WGS) technologies as primary research tools has allowed for the detection of genetic diversity in Mycobacterium tuberculosis (Mtb) with unprecedented...
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Antibacterial activities of dendritic amphiphiles against nontuberculous mycobacteria
03 January 2012
Joseph O. Falkinham, Richard V. Macri, Bhadreshkumar B. Maisuria, Marcelo L. Actis, Eko W. Sugandhi, André A. Williams, Alyson V. Snyder, Faunice R. Jackson, Michael A. Poppe, Liang Chen, Krithika Ganesh, Richard D. Gandour
Summary: The anti-mycobacterial activities of nine series of dicarboxyl and tricarboxyl dendritic amphiphiles with one alkyl, two alkyl, and cholestanyl tails against Mycobacterium abscessus, Mycobact...
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MTCID: A database of genetic polymorphisms in clinical isolates of Mycobacterium tuberculosis
30 December 2011
Richa Bharti, Ram Das, Pragya Sharma, Kiran Katoch, Alok Bhattacharya
Summary: Tuberculosis (TB) is a major cause of morbidity and mortality throughout the world, particularly in developing countries. The response of the patients and treatment outcome depends, in additi...
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