Tuberculosis
Volume 90, Issue 2 , Pages 145-151 , March 2010

Breath biomarkers of active pulmonary tuberculosis

  • Michael Phillips

      Affiliations

    • Menssana Research Inc., 1 Horizon Road, Suite 1415, Fort Lee, NJ 07024-6510, United States
    • Department of Medicine, New York Medical College, Valhalla, NY, United States
    • Corresponding Author InformationCorresponding author. Menssana Research Inc., 1 Horizon Road, Suite 1415, Fort Lee, NJ 07024-6510, United States. Tel./fax: +1 201 886 7004.
    • ,
  • Victoria Basa-Dalay

      Affiliations

    • Tuberculosis Research Unit, Angelo King Medical Research Center, De La Salle Health Sciences Institute, Cavite, Philippines
    • Tel.: +63 46 416 0226x238.
    • ,
  • Graham Bothamley

      Affiliations

    • Department of Respiratory Medicine, Homerton University Hospital NHS Foundation Trust, London E9 6SR, England, UK
    • Tel.: +44 (0) 20 8510 7814.
    • ,
  • Renee N. Cataneo

      Affiliations

    • Menssana Research Inc., 1 Horizon Road, Suite 1415, Fort Lee, NJ 07024-6510, United States
    • Tel.: +1 973 643 5464.
    • ,
  • Phung Kim Lam

      Affiliations

    • Division of Pulmonary and Critical Care Medicine, University of California San Diego, 200 West Arbor Drive, San Diego, CA 92103-8374, USA
    • Tel.: +1 619 543 5550; fax: +1 619 543 3276.
    • ,
  • Maria Piedad R. Natividad

      Affiliations

    • Center for Respiratory Medicine, The University of Santo Tomas Hospital (USTH), España Boulevard, Manila 1008, Philippines
    • Tel.: +63 (02) 731 3001.
    • ,
  • Peter Schmitt

      Affiliations

    • Schmitt & Associates, 211 Warren St, Newark, NJ 07103, United States
    • Tel.: +1 973 733 2225.
    • ,
  • James Wai

      Affiliations

    • Menssana Research Inc., 1 Horizon Road, Suite 1415, Fort Lee, NJ 07024-6510, United States
    • Tel.: +1 973 643 5464.

Received 27 October 2009 ,Revised 18 January 2010 ,Accepted 26 January 2010.

References 

  1. Anon . World TB Day – March 24, 2008. MMWR. 2008;57(11):281
  2. Zar HJ. Global paediatric pulmonology: out of Africa. Paediatr Respir Rev. 2006;7(Suppl. 1):S226–S228
  3. Perkins MD, Cunningham J. Facing the crisis: improving the diagnosis of tuberculosis in the HIV era. J Infect Dis. 2007;196(Suppl. 1):S15–S27
  4. Cho SN, Brennan PJ. Tuberculosis: diagnostics. Tuberculosis (Edinb). 2007;87(Suppl. 1):S14–S17
  5. Pavlou AK, Turner AP. Sniffing out the truth: clinical diagnosis using the electronic nose. Clin Chem Lab Med. 2000;38(2):99–112
  6. Zhang Y, Zhuang Y, Liu Z, Ruan J. Identification of twenty-eight species mycobacteria with their cellular fatty acids by capillary gas chromatography, Wei Sheng Wu Xue Bao. 1991;31(3):187–197
  7. Syhre M, Chambers ST. The scent of Mycobacterium tuberculosis. Tuberculosis (Edinb). 2008;88(4):317–323
  8. Phillips M, Cataneo RN, Greenberg J, Gunawardena R, Naidu A, Rahbari-Oskoui F. Effect of age on the breath methylated alkane contour, a display of apparent new markers of oxidative stress. J Lab Clin Med. 2000;136(3):243–249
  9. Kharitonov SA, Barnes PJ. Biomarkers of some pulmonary diseases in exhaled breath. Biomarkers. 2002;7(1):1–32
  10. Phillips M, Altorki N, Austin JH, et al. Detection of lung cancer using weighted digital analysis of breath biomarkers. Clin Chim Acta; Int J Clin Chem. 2008;393(2):76–84
  11. Phillips M, Boehmer J, Cataneo R, et al. Heart allograft rejection: detection with breath alkanes in low levels (the HARDBALL study). J Heart Lung Transpl. 2004;23:701–708
  12. Braden B, Lembcke B, Kuker W, Caspary WF. 13C-breath tests: current state of the art and future directions. Dig Liver Dis. 2007;39:795–805
  13. Phillips M. Method for the collection and assay of volatile organic compounds in breath. Anal Biochem. 1997;247(2):272–278
  14. Phillips M, Altorki N, Austin JH, et al. Prediction of lung cancer using volatile biomarkers in breath. Cancer Biomark. 2007;3(2):95–109
  15. Phillips M, Cataneo RN, Condos R, et al. Volatile biomarkers of pulmonary tuberculosis in the breath. Tuberculosis (Edinb). 2007;87(1):44–52
  16. Suzuki S. Conditional relative odds ratio and comparison of accuracy of diagnostic tests based on 2×2 tables. J Epidemiol/Jpn Epidemiol Assoc. 2006;16(4):145–153
  17. Phillips M, Greenberg J, Awad J. Metabolic and environmental origins of volatile organic compounds in breath. J Clin Pathol. 1994;47(11):1052–1053
  18. Cook NR. Statistical evaluation of prognostic versus diagnostic models: beyond the ROC curve. Clin Chem. 2008;54(1):17–23
  19. Zou YY, Yang J, Zhu J. A robust statistical procedure to discover expression biomarkers using microarray genomic expression data. J Zhejiang Univ Sci. 2006;7(8):603–607
  20. Ma S, Song X, Huang J. Regularized binormal ROC method in disease classification using microarray data. BMC Bioinform. 2006;7:253
  21. Phillips M, Altorki N, Austin J, et al. Detection of lung cancer using weighted digital analysis of breath biomarkers. Clin Chim Acta. 2008;393:76–84
  22. Michiels S, Koscielny S, Hill C. Prediction of cancer outcome with microarrays: a multiple random validation strategy. Lancet. 2005;365(9458):488–492
  23. Kneepkens CM, Lepage G, Roy CC. The potential of the hydrocarbon breath test as a measure of lipid peroxidation. Free Radic Biol Med. 1994;17(2):127–160
  24. Lamsal M, Gautam N, Bhatta N, Toora BD, Bhattacharya SK, Baral N. Evaluation of lipid peroxidation product, nitrite and antioxidant levels in newly diagnosed and two months follow-up patients with pulmonary tuberculosis. Southeast Asian J Trop Med Public Health. 2007;38(4):695–703
  25. Kwiatkowska S, Piasecka G, Zieba M, Piotrowski W, Nowak D. Increased serum concentrations of conjugated diens and malondialdehyde in patients with pulmonary tuberculosis. Respir Med. 1999;93(4):272–276
  26. Gatner EM, Burkhardt KR. Correlation of the results of X-ray and sputum culture in tuberculosis prevalence surveys. Tubercle. 1980;61(1):27–31
  27. Wilcke JT, Kok-Jensen A. Diagnostic strategy for pulmonary tuberculosis in a low-incidence country: results of chest X-ray and sputum cultured for Mycobacterium tuberculosis. Respir Med. 1997;91:281–285
  28. Lasko TA, Bhagwat JG, Zou KH, Ohno-Machado L. The use of receiver operating characteristic curves in biomedical informatics. J Biomed Inform. 2005;38:404–415
  29. Pauling L, Robinson AB, Teranishi R, Cary P. Quantitative analysis of urine vapor and breath by gas–liquid partition chromatography. Proc Natl Acad Sci U S A. 1971;68:2374–2376
  30. Phillips M, Herrera J, Krishnan S, Zain M, Greenberg J, Cataneo RN. Variation in volatile organic compounds in the breath of normal humans. J Chromatogr B Biomed Sci Appl. 1999;729(1–2):75–88
  31. Stern NJ, Kotula AW, Pierson MD. Differentiation of selected Enterobacteriaceae by pyrolysis–gas–liquid chromatography. Appl Environ Microbiol. 1979;38(6):1098–1102
  32. Stern NJ, Kotula AW, Pierson MD. Virulence prediction of Yersinia enterocolitica by pyrolysis gas–liquid chromatography. Appl Environ Microbiol. 1980;40(3):646–651
  33. Catanzaro A, Lam P, Bothamley G, et al. Using clinical suspicion of tuberculosis (CSTB) to evaluate a rapid lateral flow (RLF) serologic immunoassay. Am J Respir Crit Care Med. 2007;175:A576
  34. Laakso O, Haapala M, Jaakkola P, et al. The use of low-resolution FT-IR spectrometry for the analysis of alcohols in breath. J Anal Toxicol. 2000;24(4):250–256
  35. Ueno M, Shinada K, Yanagisawa T, et al. Clinical oral malodor measurement with a portable sulfide monitor. Oral Dis. 2008;14(3):264–269
  36. Hockstein NG, Thaler ER, Lin Y, Lee DD, Hanson CW. Correlation of pneumonia score with electronic nose signature: a prospective study. Ann Otol Rhinol Laryngol. 2005;114(7):504–508
  37. FDA website for Heartsbreath: http://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/DeviceApprovalsandClearances/Recently-ApprovedDevices/ucm081213.htm.
  38. Prasad R, Lath SK, Mukerji PK, Agrawal SK, Srivastava R. Clinical utility of polymerase chain reaction in patients of pulmonary tuberculosis. Ind J Tub. 2001;48:135–138

PII: S1472-9792(10)00015-6

doi: 10.1016/j.tube.2010.01.003

Tuberculosis
Volume 90, Issue 2 , Pages 145-151 , March 2010

Article Tools

* Image Usage & Resolution