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Effects of immunomodulators on liquefaction and ulceration in the rabbit skin model of tuberculosis
07 May 2012
Hongjia Sun, Xingming Ma, Guoping Zhang, Yanping Luo, Kefeng Tang, Xiaofa Lin, Hongjuan Yu, Ying Zhang, Bingdong Zhu
Summary: To better control tuberculosis (TB) epidemics in developing countries a real need exists to study the liquefaction and cavity formation that occur in pulmonary TB lesions. This report is the ...
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A novel assay detecting recall response to Mycobacterium tuberculosis: Comparison with existing assays
30 April 2012
Denise C. Hsu, John J. Zaunders, Marshall Plit, Craig Leeman, Susanna Ip, Thatri Iampornsin, Sarah L. Pett, Michelle Bailey, Janaki Amin, Sasiwimol Ubolyam, Anchalee Avihingsanon, Jintanat Ananworanich, Kiat Ruxrungtham, David A. Cooper, Anthony D. Kelleher
Summary: A strategy to reduce the burden of active TB is isoniazid preventive therapy for latent TB infection (LTBI). However, current assays used to diagnose LTBI all have limitations. In these proof...
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Low rates of synonymous mutations in sequences of Mycobacterium tuberculosis GyrA and KatG genes
23 April 2012
Vladislav Victorovich Khrustalev, Mohammad Arjomandzadegan, Eugene Victorovich Barkovsky, Leonid Petrovich Titov
Summary: Partial sequences of KatG and GyrA genes have been obtained from multi and extensively drug-resistant (MDR and XDR) clinical isolates of Mycobacterium tuberculosis. Nonsynonymous (DN) and syn...
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Non-acid-fastness in Mycobacterium tuberculosis ΔkasB mutant correlates with the cell envelope electron density
20 April 2012
Hiroyuki Yamada, Apoorva Bhatt, Radostin Danev, Nagatoshi Fujiwara, Shinji Maeda, Satoshi Mitarai, Kinuyo Chikamatsu, Akio Aono, Koji Nitta, William R. Jacobs, Kuniaki Nagayama
Summary: The acid-fastness is the most important and the most specific characteristics in mycobacteria, the mechanism of which is not clear but may be attributed to the lipid rich cell wall of this ba...
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The unsurprising story of MDR-TB resistance in India
16 April 2012
Giridhara R. Babu, Ramanan Laxminarayan
Summary: W.H.O. defines Totally Drug-Resistant Tuberculosis (TDR-TB) as Tuberculosis caused due to a virulent strain of tuberculosis that seems to be resistant to all known treatments. In a recent cor...
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