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Editorial Board
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Texas Tuberculosis Research Symposium 2011: Collaborative efforts within the State of Texas toward elimination of TB
22 December 2011
Texas has the second highest incidence rate of tuberculosis (TB) within the U.S. while the city of Houston ranks third among major U.S. metropolitan areas for new TB cases in 2010. The growing inciden...
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Janice J. Endsley,
Jeffrey K. Actor
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S1-S2
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| Discussion |
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Tuberculosis in Texas 2011 – Victories and challenges
05 December 2011
As the year 2010 came to an end, Texas (like most of the United States) found itself watching its number of tuberculosis cases declining. It was at once a cause for celebration and a cause for concern...
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Lisa Armitige,
Charles Wallace
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S3-S5
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| Review Articles |
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On the pathogenesis of post primary tuberculosis: The role of bronchial obstruction in the pathogenesis of cavities
15 November 2011
Summary: Mycobacterium tuberculosis produces two distinct types of disease: primary and post primary tuberculosis. We recently reported that post primary tuberculosis begins in immunocompetent adults ...
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Robert L. Hunter
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S6-S10
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A current review of infection control for childhood tuberculosis
14 November 2011
Summary: Tuberculosis (TB) infection control recommendations in healthcare settings were developed to decrease nosocomial transmission from adults. In the absence of pediatric-specific guidelines, the...
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Andrea T. Cruz,
Jeffrey R. Starke
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S11-S15
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| Regular Articles |
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Giving TB wheels: Public transportation as a risk factor for tuberculosis transmission
16 November 2011
Summary: Previous geospatial analysis of the well-defined Houston Tuberculosis Initiative (HTI) database identified an association between the use of city-bus transportation (inclusive of time onboard...
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Marsha L. Feske,
Larry D. Teeter,
James M. Musser,
Edward A. Graviss
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S16-S23
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Including the third dimension: A spatial analysis of TB cases in Houston Harris County
17 November 2011
Summary: To reach the tuberculosis (TB) elimination goals established by the Institute of Medicine (IOM) and the Centers for Disease Control and Prevention (CDC), measures must be taken to speed the c...
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Marsha L. Feske,
Larry D. Teeter,
James M. Musser,
Edward A. Graviss
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S24-S33
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Snapshot of Quantiferon TB gold testing in Northern Mexico
18 November 2011
Summary: Most people infected with Mycobacterium tuberculosis have an asymptomatic condition named latent tuberculosis. These people do not have bacilli in the corporal secretions and are hard to diag...
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F. González-Salazar,
J. Vargas-Villarreal,
F.J. Garcialuna-Martínez,
G. Rivera,
M.G. Moreno-Treviño,
J.M. Montfort-Gardeazabal,
E. Garcialuna-Martínez
et al.
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S34-S37
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Co-morbidities associated with tuberculosis in an autopsy case series
15 November 2011
Summary: A retrospective review of cases of tuberculosis examined by our Autopsy Division was undertaken to determine the most common associated co-morbidities. Forty-six cases of tuberculosis were ex...
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Elena Sbrana,
Joy Grise,
Clarke Stout,
Judith Aronson
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S38-S42
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Rapid DNA extraction for specific detection and quantitation of Mycobacterium tuberculosis DNA in sputum specimens using Taqman assays
16 November 2011
Summary: Rapid tuberculosis (TB) detection is critical for disease control, and further quantitation of Mycobacterium tuberculosis (Mtb) in sputum is valuable for epidemiological and clinical studies....
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Diana I. Gomez,
Caroline S. Mullin,
Francisco Mora-Guzmán,
J. Gonzalo Crespo-Solis,
Susan P. Fisher-Hoch,
Joseph B. McCormick,
Blanca I. Restrepo
et al.
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S43-S48
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A quality assessment tool for tuberculosis control activities in resource limited settings
16 November 2011
Summary: Tuberculosis (TB) is a significant problem, infecting nearly 9 million new patients per year and killing about 2 million a year. The primary means with which to affect TB globally are to decr...
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Katherine McQuade Billingsley,
Nathaniel Smith,
Rhett Shirley,
Loice Achieng,
Philip Keiser
et al.
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S49-S53
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Toward a low-cost compact array microscopy platform for detection of tuberculosis
14 November 2011
Summary: This paper describes the development of a microscope array capable of imaging separate fields of view without the need for opto-mechanical scanning components. This microscope array can be in...
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Brian McCall,
Mark Pierce,
Edward A. Graviss,
Rebecca Richards-Kortum,
Tomasz Tkaczyk
et al.
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S54-S60
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Characterization of clioquinol and analogues as novel inhibitors of methionine aminopeptidases from Mycobacterium tuberculosis
24 November 2011
Summary: Mycobacterium tuberculosis, the causative agent of tuberculosis claims about five thousand lives daily world-wide, while one-third of the world is infected with dormant tuberculosis. The incr...
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Omonike Olaleye,
Tirumalai R. Raghunand,
Shridhar Bhat,
Curtis Chong,
Peihua Gu,
Jiangbing Zhou,
Ying Zhang,
William R. Bishai,
Jun O. Liu
et al.
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S61-S65
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Random inducible controlled expression (RICE) for identification of mycobacterial virulence genes
14 November 2011
Summary: We have developed Random Inducible Controlled Expression (RICE), a high throughput genetic approach to identify regulated virulence pathways in pathogenic mycobacteria. RICE allows expression...
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Harish K. Janagama,
Hany A. Hassounah,
Suat L.G. Cirillo,
Jeffrey D. Cirillo
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S66-S68
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Prolonged survival of scavenger receptor class A-deficient mice from pulmonary Mycobacterium tuberculosis infection
16 November 2011
Summary: The present study tested the hypothesis that the scavenger receptor SR-A modulates granuloma formation in response to pulmonary infection with Mycobacterium tuberculosis (MTB). To test this h...
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Zvjezdana Sever-Chroneos,
Amy Tvinnereim,
Robert L. Hunter,
Zissis C. Chroneos
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S69-S74
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Activation of NK cell granulysin by mycobacteria and IL-15 is differentially affected by HIV
18 November 2011
Summary: NK cells play an important role in innate immunity to mycobacteria and are a significant source of the bactericidal effector molecule granulysin. Defects in NK cells have been described in HI...
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Alison Hogg,
Matthew Huante,
Asiko Ongaya,
Jessica Williams,
Monique Ferguson,
Miles Cloyd,
Evans Amukoye,
Janice Endsley
et al.
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S75-S81
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A defect in the synthesis of Interferon-γ by the T cells of Complement-C5 deficient mice leads to enhanced susceptibility for tuberculosis
07 December 2011
Summary: Interferon-γ (IFNγ) plays a major role during host defense against Mycobacterium tuberculosis (Mtb). T cells produce IFNγ in response to IL-12 and IL-18 secreted from Mtb infected macrophages...
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Mary Anne Mashruwala,
Amanda K. Smith,
Devin R. Lindsey,
Margaret Moczygemba,
Rick A. Wetsel,
John R. Klein,
Jeffrey K. Actor,
Chinnaswamy Jagannath
et al.
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S82-S89
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Comparing efficacy of BCG/lactoferrin primary vaccination versus booster regimen
16 November 2011
Summary: Lactoferrin is an iron binding glycoprotein possessing multiple immune modulatory activities, including ability to affect macrophage cytokine production, promote maturation of T- and B-lympho...
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Shen-An Hwang,
Kerry J. Welsh,
Sydney Boyd,
Marian L. Kruzel,
Jeffrey K. Actor
et al.
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S90-S95
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The ΔfbpA attenuated candidate vaccine from Mycobacterium tuberculosis, H37Rv primes for a stronger T-bet dependent Th1 immunity in mice
15 November 2011
Summary: The ΔfbpA candidate vaccine derived from Mycobacterium tuberculosis (H37Rv) (Mtb) protects mice better than BCG against tuberculosis, and we investigated the hypothesis that ΔfbpA may induce ...
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Cherie M. Roche,
Amanda Smith,
Devin R. Lindsey,
Akshay Meher,
Kimberly Schluns,
Ashish Arora,
Lisa Y. Armitige,
Chinnaswamy Jagannath
et al.
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S96-S104
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Influence of oral lactoferrin on Mycobacterium tuberculosis induced immunopathology
05 December 2011
Summary: The ability of lactoferrin to provide protection and decrease immunopathology in infectious diseases was evaluated using an aggressive aerosol model of Mycobacterium tuberculosis (MTB) infect...
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Kerry J. Welsh,
Shen-An Hwang,
Sydney Boyd,
Marian L. Kruzel,
Robert L. Hunter,
Jeffrey K. Actor
et al.
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S105-S113
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Immune regulatory activities of early secreted antigenic target of 6-kD protein of Mycobacterium tuberculosis and implications for tuberculosis vaccine design
12 December 2011
Summary: Although ESAT-6 was originally identified as a strong T cell immunogen in short-term culture filtrate of Mtb, and has therefore been a candidate vaccine antigen for many years, recent work ha...
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Buka Samten,
Xisheng Wang,
Peter F. Barnes
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S114-S118
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OsmC proteins of Mycobacterium tuberculosis and Mycobacterium smegmatis protect against organic hydroperoxide stress
16 November 2011
Summary: Bacterial antioxidants play a critical role in the detoxification of endogenously and host derived oxidative radicals during host–pathogen interactions. Recently, the osmotically induced bact...
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Sankaralingam Saikolappan,
Kishore Das,
Smitha J. Sasindran,
Chinnaswamy Jagannath,
Subramanian Dhandayuthapani
et al.
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S119-S127
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ChiZ levels modulate cell division process in mycobacteria
17 November 2011
Summary: We have previously shown that expression of chiZ (Rv2719c), encoding a cell wall hydrolase, is upregulated in response to DNA damaging agents and exposure to cephalexin. Furthermore, increase...
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Indumathi S. Vadrevu,
Hava Lofton,
Krishna Sarva,
Ewelina Blasczyk,
Renata Plocinska,
Jagannath Chinnaswamy,
Murty Madiraju,
Malini Rajagopalan
et al.
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S128-S135
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Replacement of Mycobacterium smegmatis dnaA gene by Mycobacterium tuberculosis homolog results in temperature sensitivity
23 November 2011
Summary: The genetic aspects of DnaA mediated initiation of oriC replication in mycobacteria are largely unknown. To get insights into the replication initiation process in mycobacteria, we characteri...
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Murty Madiraju,
Sai Chandanda Madiraju,
Kohji Yamamoto,
Rebecca Greendyke,
Malini Rajagopalan
et al.
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S136-S141
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The β-propeller gene Rv1057 of Mycobacterium tuberculosis has a complex promoter directly regulated by both the MprAB and TrcRS two-component systems
18 November 2011
Summary: The β-propeller gene Rv1057 of Mycobacterium tuberculosis is activated by envelope stress and was first characterized as a regulatory target of the TrcRS two-component system (TCS). Rv1057 ex...
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Xiuhua Pang,
Guangxiang Cao,
Pierre F. Neuenschwander,
Shelley E. Haydel,
Guihua Hou,
Susan T. Howard
et al.
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S142-S149
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Localization of acidic phospholipid cardiolipin and DnaA in mycobacteria
06 December 2011
Summary: Acidic phospholipids such as cardiolipin (CL) have been shown to modulate Mycobacterium tuberculosis (Mtb) DnaA interactions with ATP. In the present study, using nonyl acridine orange fluore...
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Erin Maloney,
Sai Chandana Madiraju,
Malini Rajagopalan,
Murty Madiraju
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S150-S155
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